Development of high producing cell lines for recombinant protein production

As part of an ILB and the state Brandenburg innovation project, InVivo works on the development of a new reporter system and optimized expression vectors for generating high producing CHO and HEK cell lines. One goal of this new method is to shorten the timeline from order entry to completion and to increase the titer of recombinant protein expression significantly. For reduction of lead time, InVivo is working on a new selection method using a cell sorter combined with reporter gene systems, making the limited-dilution approach redundant. To combine the reporter system with the realization of high expression rates, InVivo develops a new reporter and expression vector system.