Anti-human Brain drived Tau mAb 2B8
Tau protein is a microtubule-associated protein mainly found in neurons, that regulates microtubule stability and axonal transport. It is classified as an intrinsically disordered protein, allowing it to adopt multiple conformations and interact with diverse cellular partners.
The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.
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Tau protein is a microtubule-associated protein mainly found in neurons, that regulates microtubule stability and axonal transport. It is classified as an intrinsically disordered protein, allowing it to adopt multiple conformations and interact with diverse cellular partners. Tau proteins contain numerous potential phosphorylation sites that regulate it´s conformational changes and interactions. In pathological states, especially neurodegenerative disorders, hyperphosphorylation arises, leading to aggregation into neurofibrillary tangles - a hallmark of tauopathies like Alzheimer's disease. Studies, aiming to develop AT(N) blood biomarkers, show that plasma total tau poorly correlates with CSF total tau and overlaps across diagnostic groups. This is due to tau production in peripheral tissues (e.g., heart, kidney), which dominate blood tau levels. The key distinction lies in splicing: CNS tau lacks exon 4a, present in PNS isoforms between exons 4 and 5. The anti-human brain-derived TAU mAb 2B8 addresses this by selectively binding the exon 4–5 junction in CNS tau, without recognizing peripheral isoforms containing exon 4a. The clone 2B8 is a Monoclonal mouse antibody against Human TAU441 (2N4R) all isoforms, TAU total in CSF, brain derived TAU, Microtubule-associated protein tau (MAPT) (Uniprot: B3KTM0). The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.
| Product-ID: | INV4000042 |
|---|---|
| Clone: | 2B8 |
| Immunogen: | Animals were immunized with human TAU441 (2N4R) |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1k |
| Formulation: | Clear Liquid, PBS, pH 7.4 |
| Concentration: | > 1.0 mg/ml |
| Purity: | > 95% by SDS-PAGE |
| Sizes available: | 0.1 mg and 1.0 mg |
| Storage: | at - 20 °C (repeated thawing and freezing should be avoided) |
| Tested application(s): | ELISA, Western Blot, Immunhistochemistry, Immunoprecipitation, SIMOA, Luminex |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] – Mark S. Forman, Virginia M.-Y. Lee, John Q. Trojanowski. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies, Journal of Chemical Neuroanatomy, Volume 20, Issues 3–4, 2000, Pages 225-244, ISSN 0891-0618, https://doi.org/10.1016/S0891-0618(00)00100-9. |
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| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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