Anti-human a-Synuclein mAb 10D2

Anti-human a-Synuclein mAb 10D2

ID: INV4000049 Category:

α-Synuclein is a highly abundant neuronal protein (0.5–1% of total brain protein), concentrated at presynaptic terminals. It supports membrane stability, presynaptic signaling, and vesicular trafficking.

The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.

In stock

Delivery time: 2-5 days

From: 326,00 € Excl. VAT and delivery costs

Please contact us for larger quantities.

α-Synuclein is a highly abundant neuronal protein (0.5–1% of total brain protein), concentrated at presynaptic terminals. It supports membrane stability, presynaptic signaling, and vesicular trafficking. In its normal state, α-synuclein is a small, soluble protein that associates with phospholipid membranes, adopting an amphipathic α-helical structure upon lipid binding. Under pathological conditions, however, it is highly increased and adopts a neurotoxic β-sheet conformation, driving aggregation, fibril formation, and deposition in Lewy bodies, which are a hallmark of Parkinson's disease and other synucleinopathies. These misfolded aggregates are thought to disrupt cellular processes and contribute to neuronal dysfunction and death.

The clone 10D2 is a Monoclonal Mouse antibody against Human human a-Synuclein, SNCA (Uniprot: H6UYS7).

The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.

Product-ID: INV4000049
Clone: 10D2
Immunogen: Animals were immunized with recombinant human a-Synuclein
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1k
Formulation: Clear Liquid, PBS, pH 7.4
Concentration: > 1.0 mg/ml
Purity: > 95% by SDS-PAGE
Sizes available: 0.1 mg and 1.0 mg
Storage: at - 20 °C (repeated thawing and freezing should be avoided)
Tested application(s): ELISA, Western Blot, Immunhistochemistry

The product is for research use only and not for use in diagnostic or therapeutic procedures.

Additional information

Literature

[1] – Tofaris GK. Initiation and progression of α-synuclein pathology in Parkinson’s disease. Cell Mol Life Sci. 2022 Mar 26;79(4):210. doi: 10.1007/s00018-022-04240-2. PMID: 35347432; PMCID: PMC8960654.
[2] – Atik A, Stewart T, Zhang J. Alpha-Synuclein as a Biomarker for Parkinson’s Disease. Brain Pathol. 2016 May;26(3):410-8. doi: 10.1111/bpa.12370. PMID: 26940058; PMCID: PMC6245641.
[3] – Burré J, Sharma M, Südhof TC. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a024091. doi: 10.1101/cshperspect.a024091. PMID: 28108534; PMCID: PMC5519445.
References:
a. Stein JA, Kaes M, Smola S, Schulz-Schaeffer WJ. Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas. Front Neurol. 2023 Jul 13;14:1229641. doi: 10.3389/fneur.2023.1229641. PMID: 37521293; PMCID: PMC10374362.
b. Unterberger U, Lachmann I, Voigtländer T, Pirker W, Berghoff AS, Flach K, Wagner U, Geneste A, Perret-Liaudet A, Kovacs GG. Detection of disease-associated α-synuclein in the cerebrospinal fluid: a feasibility study. Clin Neuropathol. 2014 Sep-Oct;33(5):329-34. doi: 10.5414/np300796. PMID: 25131945; PMCID: PMC4151342.
c. Kovacs GG, Wagner U, Dumont B, Pikkarainen M, Osman AA, Streichenberger N, Leisser I, Verchère J, Baron T, Alafuzoff I, Budka H, Perret-Liaudet A, Lachmann I. An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology. Acta Neuropathol. 2012 Jul;124(1):37-50. doi: 10.1007/s00401-012-0964-x. Epub 2012 Feb 28. PMID: 22370907.
Document

Product Information Sheet – INV4000049
Protocol

Recommendations for Use
Notice

The product is for research use only and not for use in diagnostic or therapeutic procedures.

Reviews

There are no reviews yet.

Be the first to review “Anti-human a-Synuclein mAb 10D2”