Recombinant antibody production

Give your unique antibody to our expert hands

At InVivo, your recombinant antibody production is in reliable hands. Recombinant antibodies for target screening, antigen production or drug discovery can be produced either by transient expression or from your own stable cell line in small to large scales. Transient expression is performed using our in house system InVEST. InVEST guarantees an approximately 80 fold increase in yield compared to commercially available systems, at reduced costs. Within the last 20 years, our experts have acquired significant expertise by producing all kinds of antibodies from humans, rat or mouse.
We are ready for the challenge and look forward to working with your hard-to-express proteins!

Recombinant antibody production within a few weeks

Recombinant antibody production by transient expression

Mammalian derived antibodies within only 8 weeks!

  • Guaranteed delivery of 40 mg
  • High yield up to 2000 mg
  • Free of endotoxin and aggregates
  • High reproducibility

RECOMBINANT ANTIBODY PRODUCTION BY TRANSIENT EXPRESSION

InVEST, our proprietary and highly optimized system for transient gene expression, allows an increase in production up to 80-fold compared to standard systems. InVEST combines an optimized cell line and vector system, a novel transfection reagent with proprietary mediums. All components are synergistically optimized for a cost-efficient production of recombinant antibodies in high yields.

Special services:

  • Modifications like subclass switching or insertion of mutations in both domains
  • Transient transfection of HEK or CHO cell lines
  • Up to 100 parallel small-scale productions for target discovery
  • Upscale to gram-scale production

Recombinant antibody production from your stable cell line

Recombinant antibodies within only 8 weeks!

  • High yield up to 1 kg
  • Expert technical support for challenging cell lines
  • Batch-to-batch uniform supply
  • Free of endotoxin and aggregates

RECOMBINANT ANTIBODY PRODUCTION FROM YOUR STABLE CELL LINE

Your suspension cell line is in good hands with us – even a challenging one! We have the appropriate equipment and know-how to handle tricky cases. Your cell line is processed according to its specific requirement regarding cultivation and purification methods.

Special services

  • High cell density cultivation up to 100 L
  • Long-term cultivation
  • Scalable fed-batch process with optimized feeding regimen
  • Cryopreservation of clones

Rely on our expertise in recombinant antibody production

 

>1 000 projects successfully completed
Constant high quality for more than 20 years

Capacities

  • 75 productions in parallel
  • Bulk orders up to 1 kg
  • 2 L to 100 L bioreactors

Cutting edge equipment

  • ÄKTApilot chromatography system
  • Smart Line HPLC
  • Capillary gel electrophoresis
  • Endosafe

Optimized processes

  • Serum-free cultivation
  • Continuous fermentation
  • High cell density cultivation

Highly-developed techniques

  • Perfusion technology
  • InVEST expression system
  • High expression vector pINV
  • HEK-INV cell line
  • Large scale plasmid preparation

Advanced in-house consumables

  • Transient transfection medium
  • Polycationic transfection reagent

Premium protein purification

  • Diverse affinity chromatography techniques
  • Preparative SEC and IEX
  • Endotoxin removal

Quality assurance

  • Fully confidential data protection
  • GMP-compliant documentation
  • ISO 9001:2015 & ISO 13485:2016 certified

Contact Us

Invivo Biotech Services

Neuendorfstr. 24a
16761 Hennigsdorf
Germany

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