Anti-human TDP43 mAb 21B2
TDP-43 (transactive response DNA binding protein of 43 kDa), encoded by the TARDBP gene, is a nuclear protein involved in RNA splicing, trafficking, stabilization, and gene expression regulation.
The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.
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TDP-43 (transactive response DNA binding protein of 43 kDa), encoded by the TARDBP gene, is a nuclear protein involved in RNA splicing, trafficking, stabilization, and gene expression regulation. In disease, TDP-43 is depleted from the nucleus, mislocalized to the cytoplasm, and accumulated in insoluble aggregates with multiple posttranslational modifications (such as ubiquitination, phosphorylation, and truncation) that may also contribute to neurotoxicity in TDP-43 proteinopathies. TDP-43 inclusion bodies are characteristic of amyotrophic lateral sclerosis (ALS) and certain forms of frontotemporal lobar degeneration (FTLD) and are also observed in Alzheimer’s disease (AD) cases.
The clone 21B2 is a Monoclonal Mouse antibody against Human Amino acids KDNKRKMDETDA of TDP43 protein, TAR DNA-binding protein 46 (Uniprot: A0A0A0N0L3).
The antibody is produced exclusively from hybridoma and purified through one-step purification with Protein-A affinity chromatography.
| Product-ID: | INV4000051 |
|---|---|
| Clone: | 21B2 |
| Immunogen: | Animals were immunized with recombinant human TDP44 |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1k |
| Formulation: | Clear Liquid, PBS, pH 7.4 |
| Concentration: | > 1.0 mg/ml |
| Purity: | > 95% by SDS-PAGE |
| Sizes available: | 0.1 mg and 1.0 mg |
| Storage: | at - 20 °C (repeated thawing and freezing should be avoided) |
| Tested application(s): | ELISA, Western Blot, Immunhistochemistry |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] – de Boer EMJ, Orie VK, Williams T, Baker MR, De Oliveira HM, Polvikoski T, Silsby M, Menon P, van den Bos M, Halliday GM, van den Berg LH, Van Den Bosch L, van Damme P, Kiernan MC, van Es MA, Vucic S. TDP-43 proteinopathies: a new wave of neurodegenerative diseases. J Neurol Neurosurg Psychiatry. 2020 Nov 11;92(1):86–95. doi: 10.1136/jnnp-2020-322983. Epub ahead of print. PMID: 33177049; PMCID: PMC7803890. |
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| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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