CTLA-4 mAb (9H10), InVivoPure+
The CTLA-4 mAb clone 9H10 antibody recognizes cytotoxic T lymphocyte antigen-4 (CTLA-4) also known as CD152.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 1 EU/mg
The CTLA-4 mAb clone 9H10 antibody recognizes cytotoxic T lymphocyte antigen-4 (CTLA-4) also
known as CD152. Antibody 9H10 has shown specific reactivity against CTLA-4 Ig but not CD4 lg,
as well as the ability to block CTLA-4 Ig by binding to B7 transfected cells. Staining of activated
T cells, but not freshly isolated T cells, is reported, as well as the ability to stain a CTLA-4
transfectant but not control transfectants. The CTLA-4 mAb (9H10) antibody has shown
effectiveness in reducing tumor growth and metastasis in preclinical models. These
characteristics make the 9H10 antibody a reliable tool for identifying and studying CTLA-4 in
various immunological contexts.
This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3607P+ |
|---|---|
| Clone: | 9H10 |
| Immunogen: | This antibody was raised by immunizing Syrian hamsters with heat-killed Staphylococcus A bacteria coated in CTLA-4. |
| Host: | Syrian Hamster |
| Clonality: | Monoclonal |
| Isotype: | IgG |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 95 % (CGE, reducing conditions) |
| ≤ 5 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 1 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J |
|---|---|
| Document | |
| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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