H-2 Kb/Db mAb (28-8-6S), InVivoPure
H-2 Kb/Db mAb (28-8-6S), InVivoPure - Image 2
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H-2 Kb/Db mAb (28-8-6S), InVivoPure

ID: AK3656P Category:

Clone 28-8-6S is a mouse monoclonal antibody that specifically binds to the murine MHC class I molecules H-2Kb and H-2Db, which are part of the H-2b haplotype commonly found in C57BL/6 mice.

This antibody is produced exclusively under serum-free conditions by hybridoma and purified with Protein-A or Protein-G affinity chromatography.

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Endotoxin level ≤ 2 EU/mg

Clone 28-8-6S is a mouse monoclonal antibody that specifically binds to the murine MHC class I molecules H-2Kb and H-2Db, which are part of the H-2b haplotype commonly found in C57BL/6 mice. These molecules are essential for presenting endogenous peptides to CD8⁺ cytotoxic T lymphocytes, playing a central role in immune surveillance and response to infection and cancer.

H-2Kb and H-2Db are critical for presenting intracellular antigens to CD8⁺ T cells. This antibody is widely used in immunological research, including studies on viral immunity, tumor immunology, and neuroimmune interactions. It is also valuable in transgenic mouse models and vaccine development. This antibody has been reported to be used in immunofluorescence, immunohistochemistry, and flow cytometry.

This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.

 

 

Product-ID: AK3656P
Clone: 28-8-6S
Immunogen: Spleen cells from C3H.SW mice
Host: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG2a, kappa
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1.00 mg/mL
Purity: ≥ 90 % (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Endotoxin: ≤ 2 EU/mg (LAL test)
Storage: 2 - 8 °C
Recommended Isotype Control: Mouse IgG2a ĸ Isotype Control (AK3399P)

 

The product is for research use only and not for use in diagnostic or therapeutic procedures.

The anti-H-2 Kb/Db monoclonal antibody (clone 28-8-6S) was purified from supernatant of HB-51™ 28-8-6S from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.

Additional information

Literature

[1] Ozato K, Sachs DH. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression. J Immunol. 1981 Jan;126(1):317-21. PMID: 6935293.
[2] Zinkernagel RM, Doherty PC. H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D; J Exp Med. 1975 Jun 1;141(6):1427-36. doi: 10.1084/jem.141.6.1427. PMID: 47901; PMCID: PMC2189841.
[3] Lee DR, Rubocki RJ, Lie WR, Hansen TH. The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens. J Exp Med. 1988 Nov 1;168(5):1719-39. doi: 10.1084/jem.168.5.1719. PMID: 3263465; PMCID: PMC2189110.
[4] Wong GH, Bartlett PF, Clark-Lewis I, Battye F, Schrader JW. Inducible expression of H-2 and Ia antigens on brain cells. Nature. 1984 Aug 23-29;310(5979):688-91. doi: 10.1038/310688a0. PMID: 6433204.
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Product Information Sheet – AK3656P
Notice

The product is for research use only and not for use in diagnostic or therapeutic procedures.

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