Endotoxin level ≤ 2 EU/mg
The BB7.2 monoclonal antibody is a well-characterized mouse IgG2b antibody that specifically recognizes HLA-A2, a major histocompatibility complex (MHC) class I molecule found in humans. This antibody is widely used in immunological research, transplantation studies, and cancer immunotherapy.
BB7.2 binds to a conformational epitope of the HLA-A2 heavy chain, typically in association with β2-microglobulin (β2m). It does not cross-react with other HLA class I alleles, making it a valuable tool for distinguishing HLA-A2+ cells from non-HLA-A2+ populations.
HLA-A2 is an important molecule in tumor immunology, as many tumor-associated antigens (e.g., NY-ESO-1, MART-1) are presented by HLA-A2 to cytotoxic T lymphocytes (CTLs). The BB7.2 antibody serves as a critical reagent in screening and validating HLA-A2-restricted T-cell responses in cancer vaccine and T-cell therapy research.
The HLA-A2 mAb (BB7.2) can be used in Flow cytometry, immunoprecipitation and Western Blot, immunohistochemistry and functional blocking assay.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: |
AK3625P |
| Clone: |
BB7.2 |
| Immunogen: |
Papain solubilized HLA-A2 |
| Host: |
Mouse |
| Clonality: |
Monoclonal |
| Isotype: |
Mouse IgG2b |
| Formulation: |
Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: |
≥ 1.00 mg/mL |
| Purity: |
≥ 90 % (CGE, reducing conditions) |
|
≤ 10 % aggregates (analytical SEC) |
| Endotoxin: |
≤ 2 EU/mg (LAL test) |
| Storage: |
2 - 8 °C |
| Recommended Isotype Control: |
Mouse IgG2b ĸ Isotype Control (AK3456P) |
| Reported Application: |
FACS ; IHC ; IF ; Fn |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
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