IFNAR-1 mAb (MAR1-5A3), InVivoPure+
Anti-IFNAR-1 (clone MAR1-5A3) is a mouse monoclonal antibody targeting the extracellular domain of the murine interferon alpha/beta receptor subunit 1 (IFNAR-1).
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 1 EU/mg
Anti-IFNAR-1 (clone MAR1-5A3) is a mouse monoclonal antibody targeting the extracellular domain of the murine interferon alpha/beta receptor subunit 1 (IFNAR-1). It is widely used to block type I interferon signaling in both in vitro and in vivo models. The antibody was developed by immunizing mice via hydrodynamic transfection, a method that induces strong immune responses against membrane proteins.
MAR1-5A3 has been shown to effectively inhibit IFN-α/β signaling, making it a valuable tool in studies of viral pathogenesis, autoimmune diseases, and tumor immunology. It is used in neutralization assays, flow cytometry, and functional studies to dissect the role of type I IFNs in immune responses.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3654P+ |
|---|---|
| Clone: | MAR1-5A3 |
| Immunogen: | Extracellular domain of murine IFNAR1 |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | Mouse IgG1 |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 95 % (CGE, reducing conditions) |
| ≤ 5 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 1 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
| Recommended Isotype Control: | Mouse IgG1 ĸ Isotype Control (AK3421P+) |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] Sheehan KC, Lai KS, Dunn GP, Bruce AT, Diamond MS, Heutel JD, Dungo-Arthur C, Carrero JA, White JM, Hertzog PJ, Schreiber RD. Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection. J Interferon Cytokine Res. 2006 Nov;26(11):804-19. doi: 10.1089/jir.2006.26.804. PMID: 17115899. |
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| Document | |
| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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