Recombinant protein production

InVivo is your partner for solutions to your protein expression challenges. Our capabilities and over 20 years of expertise allow us to work on highly specific recombinant proteins and deliver promptly with consistently high quality. Our scientific experts have realized over 1000 projects for companies worldwide using optimized techniques and state-of-the-art equipment. Your protein of choice can be expressed in bacterial and mammalian systems or from your own stable cell line in small to large-scale productions.

We work according to your specifications so you can focus on the progress of your project!

COVID-19 Antigens

Tools for Research and Assay Development

InVivo offers various versions of the SARS-CoV-2 Spike (S) protein that are transiently expressed in HEK cells. These mammalian-derived recombinant proteins can be used for serological detection of COVID-19 antibodies in immunoassays, such as ELISA and Lateral Flow tests.

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Entrust your recombinant protein production to our expertise

Customized Production

Customized Production

Quantity, structure, purity, post-translational modifications

HIGH YIELD

High Yield

Large scale production or many parallel small scale productions

Fast Turnaround

Fast Turnaround

Immediate start
Production within weeks

Premium quality

Premium Quality

High purity
High reproducibility
cGMP compliant documentation

Economical production

Economical Production

Cost-efficient processes
License-free products

Transparent collaboration

Transparent Collaboration

Joint decisions
Confidential handling of data and material
Product exclusivity

Customized Production

Quantity, structure, purity, post-translational modifications

High Yield

Large scale production or many parallel small scale productions

Fast Turnaround

Immediate start
Production within weeks

Premium Quality

High purity
High reproducibility
cGMP compliant documentation

Economical Production

Cost-efficient processes
License-free products

Transparent Collaboration

Joint decisions
Confidential handling of data and material
Product exclusivity

A suitable expression system for every project

Recombinant protein production in E. coli

4 weeks from plasmid to protein

  • Non-complex proteins
  • High yield up to 5 g/batch
  • Excellent price-performance ratio
Additional Information

RECOMBINANT PROTEIN PRODUCTION IN E. COLI

The E. coli expression system for production of recombinant proteins offers several advantages: A shorter timeline for the entire process from cloning to protein recovery, inexpensive production processes, high protein yields and high flexibility in scale. Smaller peptides and proteins without posttranslational modifications, like antigens, bacterial proteins, hormones, pro-hormones, tumor markers or cytokines, are readily expressed in bacterial cells.

Special services

  • Small-scale pilot production as feasibility test
  • Cultivation in 0.8 L up to 50 L or high cell density cultivation in 10 L

Recombinant protein production in mammalian cells

3 weeks from plasmid to protein

  • Complex native proteins
  • High yield up to 2 000 mg
  • Free of endotoxins and aggregates
Additional InformationLearn more about our gene expression services!

RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS

Get mammalian derived proteins within weeks! Our proprietary optimized expression system for transient gene expression InVEST facilitates fast production of recombinant proteins, bypassing the time-consuming and costly generation of stable cell lines. InVEST guarantees an approximately 80‑fold increase in yield compared to commercially available systems. Complex native proteins with post-translational modifications like antigens, recombinant antibodies, antibody fragments, proteases, tumor markers or proteohormones can be expressed.

Special services

  • Transfection in HEK or CHO cell lines
  • Small-scale pilot production as feasibility test
  • Up to 100 parallel small-scale productions for target discovery

Recombinant protein production in your stable cell line

8 weeks from revitalization to protein

  • Complex proteins
  • High yield up to 1 kg
  • Free of endotoxins and aggregates
Additional Information

RECOMBINANT PROTEIN PRODUCTION IN YOUR STABLE CELL LINE

Your cell line is in good hands with us – even a challenging one! We have the appropriate equipment and know-how to handle tricky cases. We have successfully expressed and purified various types of recombinant mammalian proteins from our client’s stable cell lines such as antigens, enzymes, recombinant antibodies and biomarkers.

Special services

  • Small-scale pilot production as feasibility test
  • High cell density cultivation up to 100 L
  • Long-term cultivation
InVivo’s protein experts are happy to help to choose the right expression system!
Get your quote

Rely on our expertise in recombinant protein production

>1000 projects successfully completed
Consistent high quality for more than 20 years

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Capacities

  • 80 projects in parallel (0.5 L – 100 L)
  • 10 L to 50 L bioreactors for E. coli
  • 2 L to 100 L bioreactors for mammalian cells

Cutting-edge equipment

  • ÄKTApilot chromatography system
  • Smart Line HPLC
  • Capillary gel electrophoresis
  • Endosafe

Optimized processes

  • Continuous fermentation
  • High cell density cultivation
  • HEK-INV cell line

Highly developed techniques

  • InVEST expression system
  • High expression vector pINV
  • HEK-INV cell line
  • Large-scale plasmid preparation

Special in-house consumables

  • Serum-free hybridoma medium
  • Transient transfection medium
  • Polycationic transfection reagent
Premium protein purification

  • Diverse affinity chromatography techniques
  • Preparative SEC and IEX
  • Endotoxin removal

Quality assurance

  • Fully confidential data protection
  • GMP-compliant documentation
  • ISO 9001:2015 & ISO 13485:2016 certified
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Contact Us

Invivo Biotech Services

Neuendorfstr. 24a
16761 Hennigsdorf
Germany

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