Anti-CA15-3 Clone 136-95
Anti-CA15-3 Clone 136-95 - Image 2
Anti-CA15-3 Clone 136-95 - Image 3

Anti-CA15-3 Clone 136-95

ID: AK1146 Category:

Anti-CA15-3 Clone 136-95 is a mouse monoclonal antibody against human Cancer Antigen 15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

In stock

Delivery time: 2-5 days

From: 300,00 € Excl. VAT and delivery costs

Please contact us for larger quantities.

Anti-CA15-3 Clone 136-95 is a mouse monoclonal antibody against human Cancer Antigen
15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer [1]. CA 15-3
corresponds to the soluble form of the ~ 200 kDa transmembrane glycoprotein Mucin 1 (MUC
1) (UniProt-ID: P15941), which is produced through shedding of the MUC1 extracellular domain
or alternative splicing [2]. Serum levels of CA 15-3 and the tumor marker Carcinoembryonic
Antigen (CEA) have been shown to be elevated in patients with malignant breast tumors [3].

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK1146
Immunogen: Native CA15-3 derived from a human cell line
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b κ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 0.5 mg/ mL
Purity: ≥ 90% (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8 °C

 

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

Additional information

Literature

[1] M. J. Duffy, D. Evoy, and E. W. McDermott, “CA 15-3: Uses and limitation as a biomarker for breast cancer,”
Clin. Chim. Acta, vol. 411, no. 23–24, pp. 1869–1874, 2010, doi: 10.1016/j.cca.2010.08.039.
[2] C. L. Hattrup and S. J. Gendler, “Structure and function of the cell surface (tethered) mucins,” Annu. Rev.
Physiol., vol. 70, pp. 431–457, 2008, doi: 10.1146/annurev.physiol.70.113006.100659.
[3] Y. Fu and H. Li, “Assessing clinical significance of serum CA15-3 and carcinoembryonic antigen (CEA) levels in
breast cancer patients: A meta-analysis,” Med. Sci. Monit., vol. 22, pp. 3154–3162, 2016, doi:
10.12659/MSM.896563.
Document

Product Information Sheet – AK1146
Notice

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

Reviews

There are no reviews yet.

Be the first to review “Anti-CA15-3 Clone 136-95”