Anti-CA19.9 376/G8
Anti-CA19.9 376/G8 - Image 2
Anti-CA19.9 376/G8 - Image 3

Anti-CA19.9 376/G8

ID: AK1052 Category:

Anti-CA19.9 376/G8 is a mouse monoclonal antibody against Carbohydrate Antigen 19-9 (CA19-9), also known as sialyl-Lewis-A antigen.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

In stock

Delivery time: 2-5 days

From: 610,00 € Excl. VAT and delivery costs

Please contact us for larger quantities.

Anti-CA19.9 376/G8 is a mouse monoclonal antibody against Carbohydrate Antigen 19-9
(CA19-9), also known as sialyl-Lewis-A antigen. Structurally, CA19-9 is a tetrasaccharide
attached to O-glycans of transmembrane proteins with glycosylated extracellular
oligosaccharide chains [1].

CA19-9 is an important serum marker for diagnosis, treatment decisions and prognosis of
pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers [2]. Still, there are usage
limitations. Amongst others, benign conditions, like pancreatitis, cirrhosis, lever fibrosis or
diabetes mellitus, resulting in increased CA19-9 levels can lead to false positive results [1].
Furthermore, the inability of some people with a Lewis (a- b-) blood genotype to produce CA19-9
can lead to false negative results [3].

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK1052
Immunogen: Native CA19-9 derived from a human cell line
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 0.5 mg/mL
Purity: ≥ 90% (CGE, reducing conditions); Two bands occur on the order of magnitude of the heavy chain
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8°C

 

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

Additional information

Literature

[1] T. Lee, T. Z. J. Teng, and V. G. Shelat, “Carbohydrate antigen 19-9 — tumor marker: Past, present, and future,”
World J. Gastrointest. Surg., vol. 12, no. 12, pp. 468–490, 2020, doi: 10.4240/wjgs.v12.i12.468.
[2] G. L. Perkins, E. D. Slater, G. K. Sanders, and J. G. Prichard, “Serum tumor markers,” Am. Fam. Physician, vol. 68,
no. 6, pp. 1075–1082, 2003, doi: 10.29309/tpmj/2006.13.01.5043.
[3] M. Parra-Robert, Víc. M. Santos, S. M. Canis, X. F. Pla, J. M. A. Fradera, and R. M. Porto, “Relationship between
CA 19.9 and the lewis phenotype: Options to improve diagnostic efficiency,” Anticancer Res., vol. 38, no. 10, pp.
5883–5888, 2018, doi: 10.21873/anticanres.12931.
Document

Product Information Sheet – AK1052
Notice

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

Reviews

There are no reviews yet.

Be the first to review “Anti-CA19.9 376/G8”