H-2Kd/H-2Dd mAb (34-1-2S), InVivoPure
H-2Kd/H-2Dd mAb (34-1-2S), InVivoPure - Image 2
H-2Kd/H-2Dd mAb (34-1-2S), InVivoPure - Image 3

H-2Kd/H-2Dd mAb (34-1-2S), InVivoPure

ID: AK3642P Category:

The anti-H2Kd/H-2Dd monoclonal antibody (clone 34-1-2S) is a mouse-derived antibody that targets MHC class I alloantigens, specifically H-2Kd and H-2Dd. The antibody is critical for antigen presentation to T cells expressing CD3/TCR and CD8 proteins.

This antibody is produced exclusively under serum-free conditions by hybridoma and purified with Protein-A or Protein-G affinity chromatography.

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Endotoxin level ≤ 2 EU/mg

The anti-H2Kd/H-2Dd monoclonal antibody (clone 34-1-2S) is a mouse-derived antibody that targets MHC class I alloantigens, specifically H-2Kd and H-2Dd. These antigens are expressed on the surface of nucleated cells in mice with the H-2Kd/H-2Dd haplotype. The antibody is critical for antigen presentation to T cells expressing CD3/TCR and CD8 proteins.

This antibody is known for its cross-reactivity with other MHC class I alloantigens, including those of the H-2Kb, H-2Ks, H-2Kr, H-2Kq, and H-2Kp haplotypes. It is commonly used in flow cytometry for the analysis of mouse splenocytes and other cell types.

This antibody is a valuable tool for researchers studying immune responses by helping to identify and characterize cells based on their MHC class I expression.

This antibody is produced exclusively under serum-free conditions by hybridoma and purified by Protein-A or Protein-G affinity chromatography.

 

 

Product-ID: AK3642P
Clone: 34-1-2S
Immunogen: Animals were immunized with spleen cells from BDF1 mice
Host: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG2a
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1.00 mg/mL
Purity: ≥ 90 % (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Endotoxin: ≤ 2 EU/mg (LAL test)
Storage: 2 - 8 °C
Recommended Isotype Control: Mouse IgG2a ĸ Isotype Control (AK3399P)

 

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

The anti-H2Kd/H-2Dd monoclonal antibody (clone 34-1-2S) was purified from supernatant of HB-79™ 34-1-2S from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.

Additional information

Literature

[1] Tryphonas M, King DP, Jones PP. Identification of a second class I antigen controlled by the K end of the H-2
complex and its selective cellular expression. Proc Natl Acad Sci U S A. 1983 Mar;80(5):1445-8. doi:
10.1073/pnas.80.5.1445. PMID: 6572399; PMCID: PMC393614.
[2] de Vries JE, Yssel H, Spits H. Interplay between the TCR/CD3 complex and CD4 or CD8 in the activation of
cytotoxic T lymphocytes. Immunol Rev. 1989 Jun;109:119-41. doi: 10.1111/j.1600-065x.1989.tb00022.x. PMID:
2527803.
[3] Ozato K, Mayer NM, Sachs DH. Monoclonal antibodies to mouse major histocompatibility complex antigens.
Transplantation. 1982 Sep;34(3):113-20. doi: 10.1097/00007890-198209000-00001. PMID: 7135466.
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Product Information Sheet – AK3642P
Notice

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

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