HLA-DQ mAb (SPV-L3), InVivoPure+
HLA-DQ monoclonal antibody (clone SPV-L3) is a mouse IgG2aκ antibody that specifically recognizes the human HLA-DQ molecule, a class II major histocompatibility complex (MHC) protein.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 1 EU/mg
HLA-DQ monoclonal antibody (clone SPV-L3) is a mouse IgG2aκ antibody that specifically recognizes the human HLA-DQ molecule, a class II major histocompatibility complex (MHC) protein. HLA-DQ is a heterodimer composed of an alpha (DQA1) and beta (DQB1) chain, both anchored in the membrane of antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages.
SPV-L3 was raised against a T4-positive cytotoxic T lymphocyte clone (HG-38) and binds a monomorphic determinant of HLA-DQ. It is widely used in flow cytometry, immunocytochemistry, immunofluorescence, and immunohistochemistry, with validated reactivity in human and porcine samples.
Importantly, SPV-L3 has been shown to block cytotoxic activity of T4-positive CTL clones, making it useful in functional assays and immune regulation studies.
This antibody is often used in transplantation research, autoimmune disease studies, and immunopeptidomics, where HLA-DQ plays a role in antigen presentation and immune recognition.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3655P+ |
|---|---|
| Clone: | SPV-L3 |
| Immunogen: | T4-positive CTL clone HG-38 |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | Mouse IgG2a, kappa |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 95 % (CGE, reducing conditions) |
| ≤ 5 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 1 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
| Recommended Isotype Control: | Mouse IgG2a ĸ Isotype Control (AK3399P+) |
The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] Hartman K, Steiner G, Siegel M, Looney CM, Hickling TP, Bray-French K, Springer S, Marban-Doran C, Ducret A. Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes. Biology (Basel). 2023 Sep 21;12(9):1265. doi: 10.3390/biology12091265. PMID: 37759665; PMCID: PMC10525474. |
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| Document | |
| Notice | The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures. |
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