NK1.1 mAb (PK136), InVivoPure+
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NK1.1 mAb (PK136), InVivoPure+

ID: AK3620P+ Category:

The PK136 monoclonal antibody is a widely used mouse IgG2a antibody that specifically recognizes NK1.1, a surface glycoprotein belonging to the NKR-P1 (CD161) family.

This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.

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Endotoxin level ≤ 1 EU/mg

The PK136 monoclonal antibody is a widely used mouse IgG2a antibody that specifically recognizes NK1.1, a surface glycoprotein belonging to the NKR-P1 (CD161) family.
This Marker is expressed on NK cells and NKT cells in certain mouse strains including C57BL/6, FVB/N and NZB. Due to its specificity, PK136 is extensively used in immunological research to study NK cell biology, innate immunity, and tumor immunology.
The PK136 antibody binds to NKR-P1C (NK1.1) on NK cells and a subset of T cells known as NKT cells in NK1.1-expressing strains. It does not cross-react with NK cells from BALB/c or other NK1.1-negative strains. In addition to Flow and IHC, this clone has also been reported to work for in-vitro and in-vivo depletion assays.

This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.

 

 

Product-ID: AK3620P+
Clone: PK136
Immunogen: Spleen enriched for NK1+ cells and bone marrow cells from CE mice
Host: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG2a
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1.00 mg/mL
Purity: ≥ 95 % (CGE, reducing conditions)
≤ 5 % aggregates (analytical SEC)
Endotoxin: ≤ 1 EU/mg (LAL test)
Storage: 2 - 8 °C
Recommended Isotype Control: Mouse IgG2a ĸ Isotype Control (AK3399P+)

 

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

The NK1.1 monoclonal antibody (clone PK136) was purified from supernatant of HB-191™ PK136 from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.

Additional information

Literature

[1] Koo GC, Peppard JR. Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma. 1984 Fall;3(3):301-3. doi:
10.1089/hyb.1984.3.301. PMID: 6500587.
[2] Vicari AP, Zlotnik A. Mouse NK1.1+ T cells: a new family of T cells. Immunol Today. 1996 Feb;17(2):71-6. doi:
10.1016/0167-5699(96)80582-2. PMID: 8808053.
[3] Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP.
Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006 Jun
15;176(12):7511-24. doi: 10.4049/jimmunol.176.12.7511. PMID: 16751398.
[4] Mathios D, Park CK, Marcus WD, Alter S, Rhode PR, Jeng EK, Wong HC, Pardoll DM, Lim M. Therapeutic
administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor
immune response in a murine glioblastoma model. Int J Cancer. 2016 Jan 1;138(1):187-94. doi:
10.1002/ijc.29686. Epub 2015 Jul 28. PMID: 26174883; PMCID: PMC4696021.
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Product Information Sheet – AK3620P+
Notice

The product is for research use or for further manufacturing only and not for use in diagnostic or therapeutic procedures.

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