De novo sequencing of mABs with QTOF MS

CeMOS – Center for Mass Spectrometry and Optical Spectroscopy, recently demonstrated in collaboration with Bruker Daltonics and InVivo the complete de novo sequencing of a human monoclonal IgG using QTOF mass spectrometry. This approach proves to be an important tool for mAb development and can supplement in silico approaches. InVivo provided a recombinant human antibody, developed as stable expressing monoclonal CHO cell line and manufactured in our bioreactor facility

All information and details are compiled in an Application Note, which you can find here
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